InSyBio is happy to announce a new scientific publication led by Filip Stojceski, titled “Molecular-level understanding of the aging bone and regeneration mechanisms using computational methods”, published in Osteoporosis International. The article is available as an open-access publication (https://doi.org/10.1007/s00198-026-07903-z )and was developed in the context of the REGENERATION project.
The publication provides a comprehensive review of current computational research on bone ageing, regeneration, and osteoporosis, with particular emphasis on how molecular dynamics, molecular docking, and bioinformatics approaches can support a deeper understanding of bone biology and contribute to the development of more targeted therapeutic strategies.
More specifically, the paper examines three major scientific areas: first, the structural interactions within the bone matrix; second, the role of key non-collagenous proteins in the mineralisation process; and third, computational strategies for drug discovery targeting pathways such as sclerostin, RANKL, and estrogen receptors. The publication also underscores the growing importance of integrating computational predictions with experimental and clinical data in order to move toward more personalised and effective approaches for the treatment of osteoporosis.
InSyBio is especially pleased to have contributed to this scientific output through the participation of Harry Zaverdas, Konstantinos Theofilatos, and Seferina Mavroudi among the co-authors. Through its involvement in REGENERATION, InSyBio works alongside academic and industrial partners to advance innovative approaches for aged bone tissue research and regenerative medicine.
Congratulations are due to Filip Stojceski of the Dalle Molle Institute for Artificial Intelligence, USI-SUPSI, for leading this publication, and to all co-authors and consortium partners involved, including Andrea Danani and Gianvito Grasso from the Dalle Molle Institute for Artificial Intelligence, USI-SUPSI; Alessia Mengoni and Mario Ledda from the Institute of Translational Pharmacology, National Research Council; Giuseppe Falvo D’Urso Labate from Cellex S.R.L.; and Athanasios Kalogeras from the Industrial Systems Institute, Athena Research Center.
The REGENERATION project is described in the source text as a Horizon Europe Marie Skłodowska-Curie Actions Staff Exchange project focused on the development of reliable and sustainable in vitro models of healthy and aged bone tissue, including models treated with Quantum Molecular Resonance (QMR), with the broader aim of enabling more personalised therapies, improved preventive care for older people, and better treatment and pain management for bone damage. The Springer article additionally states that the work was developed as part of the REGENERATION project and cites EU funding support.
This publication constitutes an important scientific contribution to the field of bone regeneration and osteoporosis research and reflects the value of interdisciplinary collaboration across computational science, bioinformatics, and translational biomedical research.
Link references
You can find the article here: https://doi.org/10.1007/s00198-026-07903-z
More information about the REGENERATION project can be found here: https://regenerationhorizon.eu/